For those of you about to install a fresh Windows 7 copy, and even for those who aren't, a handy open source multi-installer named Ninite can be a fantastic first-run application. Going to the site, you check off which applications you want within the installer and then download. Ninite will download the latest versions of the programs and install them, automatically deselecting toolbars and other pack-in crapware you don't want.
My only gripe with this would be a lack of control over what options you do want within the applications. For instance, Avast contains default options that you don't want installed such as IM and Network scanning that hampers more than helps. You can install them separately of course, but that really defeats the whole purpose.